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Judul Hesperidin Meningkatkan Efek Sitotoksik Doxorubicin pada Sel MCF-7 (Hesperidin Increase Cytotoxic Effect of Doxorubicin in MCF-7 Cells)
Edisi
No. Panggil Majalah Farmasi Indonesia 21(1)2010:8-17
ISBN/ISSN 0126-1037
Pengarang Adam Hermawan - Personal Name
Edy Melyanto - Personal Name
Ratna Asmah Susidarti - Personal Name
Subyek CYTOTOXINS
HESPERIDIN
Klasifikasi
Judul Seri
GMD Text
Bahasa Ina
Penerbit Fakultas Farmasi UGM
Tahun Terbit 2010
Tempat Terbit Yogyakarta
Deskripsi Fisik 9p.
Abstrak/Catatan Hesperidin, a flavonoid, shows strong cytotoxic effect in several cancer cell lines. The aim of this research was to investigate cytotoxic activities of hesperidin alone and in combination with doxorubicin. Cell viability assay of hesperidin, doxorubicin, and combination treatments were carried out by using
11 MTT assay. Apoptosis assay was done using double staining method using Ethidium Bromide-Acridine Orange. Hesperidin did not show cytotoxic effect but doxorubicin showed cytotoxic effect with ICso 467 nM. Hesperidin (5, 50 and 100 ~M) increased cytotoxic effect of doxorubicin compared with doxorubicin alone. The strongest cytotoxic activity was showed by the combination of 200 nM doxorubicin and 100 IJM hesperidin. Combination treatment of doxorubicin 200 nM and hesperidin 100 ~M induced apoptosis in MCF-7 cells. Hesperidin is potentially to be developed as co-chemotherapeutic agent for breast cancer, while molecular mechanism need to be explored.

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